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.Improvement of the particle size of piperine-loaded nanohydrogels in soybean oil by high-pressure homogenization with the aid of heating.
To enhance the dissolution and oral bioavailability of poorly water-soluble drug, piperine (PIP)-loaded nanohydrogels were designed by high-pressure homogenization (HPH) in an oil-in-water (O/W) emulsion. The physicochemical properties of the nanohydrogels and the dissolution behavior of PIP in the nanohydrogels were investigated. Furthermore, the mechanism of the enhancement in the dissolution and oral bioavailability of PIP by the formulation using HPH was also studied. SEM and AFM studies indicated that the optimal particle sizes of nanohydrogels were in the range of 250-280 nm. Moreover, PIP-loaded nanohydrogels obtained by HPH showed increased dissolution rate in the formulation solvent compared to that of free PIP in buffer solutions at pH 1.2 and 6.8, with a remarkably improved oral bioavailability of PIP in rats. Overall, the increase in dissolution rate and oral bioavailability of PIP-loaded nanohydrogels can be ascribed to the reduced size of PIP-loaded nanohydrogels and the enhanced diffusion ability of PIP across the gastrointestinal barrier.AKA

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After an intense police raid on a warehouse where a crew of groupies invade their apartment, Alex (Annabelle Wallis) is sent on a mission to head to Los Angeles and track down Justin (Michael Madsen). Justin has taken up with a new group of girls on the road in order to promote his new album.

There are some problems with the script; it muddles Alex’s future with her boyfriend Justin, who she takes to LA to find, and it also brings in other characters and story lines than originally planned.Pubdate: Thu, 11 Sep 2001
Source: Seattle Post Intelligencer (WA)
Copyright: 2001 Seattle Post Intelligencer
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